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185 In an uncontrolled trial that included 52 men with infertility deemed not surgically treatable, 50 mg of saffron three times weekly for three months led to improvements in sperm motility and morphology, but not sperm counts

The primary endpoint of the study was the number of treatment-related adverse events from baseline to the end of follow-up at 26 weeks, while the exploratory endpoints were changes in body weight, glycemic parameters, and various hormones

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Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval

[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Koren S, DiPilato LM, Emmett MJ, Shearin AL, Chu Q, Monks B, et al